Native SHC Protein (Shrimp Hemocyanin, SMCC-Activated, KLH substitution)
YamayBio Mariculture SHC is a purified shrimp (Penaeus vannamei)hemocyanin. It can serve as a substitute for Keyhole Limpet Hemocyanin (KLH) as a carrier protein for conjugation with low molecular weight molecules such as peptides, nucleic acids, drugs, or toxins, imparting high immunogenicity to them. Read more
Store at -20°C. Product is shipped at ambient temperature.
YamayBio Mariculture SHC is a purified shrimp (Penaeus vannamei) hemocyanin. It can serve as a substitute for Keyhole Limpet Hemocyanin (KLH) as a carrier protein for conjugation with low molecular weight molecules such as peptides, nucleic acids, drugs, or toxins, imparting high immunogenicity to them. Testing has shown that SHC exhibits comparable immunogenicity to KLH, while its solubility (especially after conjugation with haptens) is significantly higher than that of KLH, providing greater flexibility in immunogen preparation protocols.
KEY FEATURES
High-yield Conjugation One molecule of SHC contains greater than 20 primary amines available for coupling haptens via EDC or NHS ester crosslinkers.
Validated Quality Purified and stabilized mariculture SHC maintains solubility in aqueous solutions, unlike traditional carrier protein sources.
Sustainable Source SHC is harvested from select populations of Penaeus Vannamei grown in mariculture, not extracted from wild populations.
Highly Immunogenic SHC forms polymers in PBS buffer and elicits a strong immune response equivalent to KLH.
Highly Soluble The solubility of SHC-peptide conjugates is higher than that of KLH-peptide conjugates.
Straightforward Conjugation Directly mix the hapten containing a free thiol group with the SMCC-activated SHC to prepare hapten antigens.
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Specifications
| Product Type | Protein |
| Form | Dark Blue Powder |
| Quantity | 10 mg / 100 mg / 600 mg |
| Purity (MPLC-SEC) | ≥ 98% |
| Molecular Weight | 70 KD and 73 KD |
| Extinction Coefficient | 280 nm (ε = 1.277 cm⁻¹ × mg¹ × mL) |
